• Scaffold Hopping In Medicinal Chemistry
Scaffold Hopping In Medicinal Chemistry

Scaffold Hopping In Medicinal Chemistry

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RUR 14612.03

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This first systematic treatment of the concept and practice of scaffold hopping shows the tricks of the trade and provides invaluable guidance for the reader's own projects



Methods such as CATS, Feature Trees, Feature Point Pharmacophores FEPOPS , and SkelGen are discussed among many others

The final part contains three fully documented real-world examples of successful drug development projects by scaffold hopping that illustrate the benefits of the approach for medicinal chemistry

The first section serves as an introduction to the topic by describing the concept of scaffolds, their discovery, diversity and representation, and their importance for finding new chemical entities

The following part describes the most common tools and methods for scaffold hopping, whether topological, shape-based or structure-based

While most of the case studies are taken from medicinal chemistry, chemical and structural biologists will also benefit greatly from the insights presented here.

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